An airplane lands at Logan Airport in Boston. All of its passengers die from an unknown virus, which causes their skin to melt down. Phillip Broyles leads several federal agencies to investigate the accident; he orders Agent Olivia Dunham to examine a storage facility, where John Scott, who has a romantic relationship with Olivia, is infected with the virus when chasing a suspect.
To save John's life, Olivia enlists the help of Dr. Walter Bishop, a scientist versed in fringe science who has been incarcerated in a loony bin for 17 years. Walter invents a system, which enables Olivia to communicate with a comatose John. After identifying the suspect, Olivia raids his apartment, arresting him. John is saved, and Olivia finds out that he is working with the criminal. In a car chasing, John's car turns over, and he dies.
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